DS Haven In Light Of Things
Why would a treatment make symptoms worse before they improve? This clip explains the “paradoxical reaction,” a response sometimes reported when beginning thiamine therapy, particularly in people with significant deficiency. It also covers why starting with a low dose, increasing gradually, and monitoring symptoms may help make the adjustment more manageable.
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What If Parkinson’s Is Also An Energy Metabolism Problem?
Parkinson’s is often framed around dopamine, but this clip looks deeper at what may be happening inside the cell. Oxidative stress, inflammation, chronic infection, and environmental toxins can interfere with key thiamine-dependent enzymes involved in energy production, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. That raises a bigger question about whether impaired B1-dependent metabolism is part of the disease process itself.