When thiamine deficiency becomes severe, the body can lose its ability to process glucose efficiently through the mitochondria, pushing more pyruvate toward lactate and, in extreme cases, contributing to lactic acidosis. This clip explores the metabolic similarities with the Warburg effect, where cancer cells rely heavily on glycolysis and produce large amounts of lactate despite abundant glucose. At the center of the discussion is pyruvate dehydrogenase, a critical gateway between glucose metabolism and mitochondrial energy production.
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Why Mitochondrial Supplements Can Make Some People Feel Worse
If every supplement aimed at boosting mitochondrial energy makes symptoms worse, the problem may not be a lack of support. This clip explains how mold, stealth infections, and other ongoing stressors may push cells to deliberately downregulate energy production as a protective response. In that state, trying to force mitochondrial output higher can sometimes backfire until the underlying stressor is addressed.
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