Thiamine has an unusually wide safety margin compared with many other nutrients. This clip explains why even very large oral doses of B1 are generally considered well tolerated, how the body tends to limit excess absorption, and why oral supplementation is very different from injecting or infusing thiamine directly.
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How B1 Problems Can Hide In The Brain While Blood Tests Look Normal
A normal blood or urine test may still miss a thiamine problem that is localized to a specific part of the brain. This clip explains how researchers have reported region-specific or functional B1 abnormalities in Parkinson’s, Alzheimer’s, Huntington’s, and other neurodegenerative conditions, including problems with transporting thiamine into vulnerable brain tissue. It also looks at animal research using high-dose B1 with biotin, and why these findings have led to further human investigation.
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