Higher-dose thiamine was originally being used for neurological issues, but some patients also saw major improvements in problems like IBS, SIBO, and other functional gut disorders.

Methylene blue gets a lot of attention for mitochondrial support, but context matters. This clip explores its potential in areas like neurodegenerative and skin conditions while raising an important question about long-term use. Because methylene blue also has potent antimicrobial and antiparasitic activity, could prolonged use unintentionally disrupt the microbiome? Sometimes a compound's biggest strength can also become its biggest tradeoff.

Your body doesn't keep expensive metabolic machinery running when it isn't being used. This clip explains how enzymes involved in energy production can become downregulated during nutrient deficiency or changes in fuel use, and why high-dose nutrient therapy is being explored as a way to help reactivate those pathways. In chronic illness, the issue may not always be a lack of fuel. Sometimes the machinery needed to use that fuel is no longer working efficiently.