Why Thiamine Can Make You Feel Worse Before Better

This clip breaks down the paradoxical reaction with thiamine. Sometimes the people who need B1 the most are the ones who feel worse when they first start taking it. That does not automatically mean it is the wrong fit or that it is causing harm. In some cases, symptoms can temporarily flare before the body settles and starts moving in the right direction. If B1 seemed to backfire at first, this may explain why.

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What If Parkinson’s Is Also An Energy Metabolism Problem?

Parkinson’s is often framed around dopamine, but this clip looks deeper at what may be happening inside the cell. Oxidative stress, inflammation, chronic infection, and environmental toxins can interfere with key thiamine-dependent enzymes involved in energy production, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. That raises a bigger question about whether impaired B1-dependent metabolism is part of the disease process itself.